商品介绍

Product Introduction

Bioactivity

名称	Disodium monofluorophosphate
描述	Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.
体外活性	在无血清单层培养中,1 mM Monofluorophosphate诱导胚胎鸡颅骨细胞增殖速率提高三倍。 30 μM的Monofluorophosphate将颅骨细胞中DNA和碱性磷酸酶的活性分别提高了135％和178％。在培养的完整的颅骨中,30 μM的Monofluorophosphate分别使DNA活性,碱性磷酸酶活性和胶原蛋白产量增加143％,186％和151％。
体内活性	Monofluorophosphate在体内对骨固定化显示有效的活性。与不含氟化物的水组相比,含有50ppm Monofluorophosphate的饮用水显示移动胫骨和不移动胫骨的骨骼疾病明显增加(分别为1.48和0.98 mM,分别为0.79和0.40 mM）。 Monofluorophosphate增加了骨骼的矿化速率,并抵消了固定化引起的骨厚度,灰分含量和比重下降,而不改变灰分的Ca/P比率。Monofluorophosphate对大鼠的固定化和非固定化胫骨的比重无影响。
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
溶解度	DMSO : < 1 mg/mL (insoluble or slightly soluble)
关键字	pyruvate kinase \| phosphorylase phosphatase \| NSC-248 \| NSC 248 \| Disodium monofluorophosphate \| alkaline phosphatase
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