| 名称 | CP5V |
| 描述 | CP5V, a PROTAC, induces mitotic inhibition, and suppresses cancer cell proliferation. It specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. |
| 体外活性 | CP5V induces degradation of Cdc20 leading to significant inhibition of breast cancer cell proliferation and resensitization of Taxol-resistant cell lines. CP5V profoundly degrades Cdc20 in both MCF7 and MDA-MB-231 cells (DC50: about 1.6 μM). |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| 关键字 | CP5V | CP-5V |
| 相关产品 | dBET6 | ARV-471 | dBET1 | C004019 | ARV-393 HCl | Gefitinib-based PROTAC 3 | β-NF-JQ1 | NH2-PEG2-C6-Cl hydrochloride | MT-802 | GMB-475 | ACBI1 | CCT367766 |
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