| 名称 | DOTAP chloride |
| 描述 | DOTAP chloride (1, 2-dioleoyl-3-trimethylammonium-propane chloride) is an efficient cationic lipid, and its target is mainly the negatively charged components on the cell membrane. DOTAP chloride binds to negatively charged nucleic acids (such as DNA and RNA) by electrostatic interaction to form complexes, thereby achieving the delivery of nucleic acids. |
| 体外活性 | 方法：前列腺癌细胞系 PC3、黑色素瘤细胞系 M21 用DOTAP/DOPC 脂质体载体(CLs）装载紫杉醇(PTX）处理24小时,使用酶标仪在490 nm处测量吸光度检测细胞毒性。 结果：随着 PTX 含量的增加,DOTAP/DOPC CLs 的细胞毒性效果增强。[1] |
| 存储条件 | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year |
| 溶解度 | Ethanol : 130 mg/mL (186.1 mM), Sonication and heating are recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (5.73 mM), Sonication is recommended. DMSO : 125 mg/mL (178.94 mM), Sonication is recommended. |
| 关键字 | transfection | nucleic | Lipid | Inhibitor | inhibit | DOTAP chloride | DOTAP Chloride | DOTAP | Cationic Lipid | Cationic | acid | 1,2-Dioleoyl-3-trimethylammonium-propane Chloride |
| 相关产品 | Cholesterol | DSPS | 1,2-Distearoyl-sn-glycero-3-phosphorylcholine | SM-102 | Phosphatidylcholines,soya | DPPC | 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine | 1,2-dioleoyl-sn-glycero-3-phosphocholine | DODAP | 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC | ALC-0315 | D-Lin-MC3-DMA |
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