商品介绍

Product Introduction

Bioactivity

名称	Reslizumab
描述	Reslizumab (Sch 55700) is a humanized immunoglobulin G (IgG)4 κ monoclonal antibody that binds to human interleukin 5, thereby decreasing eosinophil production and survival.Reslizumab improves lung function, induces a decrease in eosinophil production and maturation, and may be used in the study of asthma.
体外活性	Reslizumab与人IL-5的结合亲和力很高,在Biacore表面等离子共振,KD=109 pM和动力学排阻实验中的,KD=4.3 pM。[1] Reslizumab 与 hIL-5 的亲和力很高(Kd = 20 pM）,能抑制 hIL-5 与 Ba/F3 细胞的结合(IC50 = 0.5 nM）,并能阻断 IL-5 介导的人类红细胞白血病 TF-1 细胞的增殖。[2]
体内活性	腹腔或肌肉注射0-10 mg/kg Reslizumab 以剂量依赖的方式抑制过敏性小鼠的肺嗜酸性粒细胞增多。静脉注射 30 mg/kg Reslizumab 可抑制过敏性豚鼠的过敏性支气管收缩,但不能抑制组胺诱导的支气管收缩。静脉注射 0.1-1 mg/kg Reslizumab 可阻断气管注射 hIL-5 引起的豚鼠肺嗜酸性粒细胞和中性粒细胞增多。静脉注射 0.3 mg/kg Reslizumab 可在过敏性绒猴体内阻断抗原挑战引起的肺嗜酸性粒细胞增多长达 6 个月。 [2]
存储条件	store at low temperature \| -20°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
关键字	Reslizumab \| ILReceptor \| IL-5-dependent cell proliferation \| IL-5 \| IL Receptor
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