Tos-PEG8-m, a PEG-based PROTAC linker, is a derivative of silybin ethers. It is utilized in the synthesis of Silymarin[1].
体外活性
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
存储条件
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