| 名称 | Propargyl-PEG1-acid |
| 描述 | Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1]. |
| 体外活性 | BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment[1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| 关键字 | Propargyl-PEG1-acid | Propargyl-PEG-1-acid | PropargylPEG1acid | Propargyl PEG1 acid | PEGs |
| 相关产品 | 6-Maleimidocapronic acid | Decaethylene glycol | 11-Aminoundecanoic acid | Pentaethylene glycol | Azido-PEG1 | N-(4-Carboxycyclohexylmethyl)maleimide | Boc-C16-COOH | Triethylene glycol | Tetraethylene glycol | Bis-Tos-PEG4 | 1,3-Dibromo-5,5-dimethylhydantoin | m-PEG12-NHS ester |
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