| 名称 | Cre mRNA |
| 描述 | Cre-mRNA is an mRNA molecule capped at the 5' end, polyadenylated at the 3' end, and modified with N1-Me-Pseudo UTP, mimicking the processed mature mRNA found in eukaryotes. The mRNA is capped co-transcriptionally using 3'-O-Me-GAG, forming a Cap1 structure which enhances mRNA stability and translation efficiency. The incorporation of the modified nucleotide N1-Me-Pseudo UTP reduces innate immune stimulation and increases mRNA stability. The addition of the poly(A) tail further stabilizes the mRNA and enhances its translation initiation efficiency. |
| 体内活性 | Cre mRNA LNP-1(0.3mg/kg,i.v）给药后48小时,Ai14小鼠肝脏中的tdTomato表达比背景组织自发荧光高几个数量级,表明载体Cre mRNA可以在Ai14小鼠中产生tdTomato信号[1]。 |
| 存储条件 | store at -80°C for 1 year |
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