| 名称 | D-3 |
| 描述 | D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent. |
| 体外活性 | D-3 prevents residual iPSC-induced teratoma formation in a mouse tumorigenicity assay[1]. D-3 induces obvious loss of viability in 201B7 cells, with half maximal inhibitory concentration value of 192.3 ± 57.4 μM[1]. D-3 induces an increase in the amount of activated elF2a, p38, and p44/42 MAPK, which are activated in response to cellular stress. D-3 also increases the number of Annexin-V and SYTOX-positive cells, indicating apoptotic and dead cells after D-3 treatment[1]. D-3 has little influence on various non-iPSCs, including hepatocytes and neurons[1]. Cell Viability Assay[1]Cell Line: Six human iPSCs lines and one human ESC line (khES1). Concentration: 400 μM. Incubation Time: 1-2 h. Result: Sufficient to induce a viability loss (>99% in all iPSC lines and >95% in khES1). |
| 存储条件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| 关键字 | D-3 | D3 | D 3 |
| 相关产品 | Cyclosporin A | Sodium orthovanadate | Tartaric acid disodium dihydrate | PTP1B-IN-22 | Cyclosporine | β-Glycerophosphate disodium salt hydrate | Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride | CaMKP Inhibitor | L-Ascorbic acid 2-phosphate trisodium | Idoxuridine | β-Glycerophosphate disodium salt pentahydrate | Tetramisole hydrochloride |
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