| 名称 | Tyr-Gly-Gly-Phe-Met-OH |
| 描述 | Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin), is a naturally occurring, endogenous opioid peptide that inhibits tumor growth via binding to the opioid receptor. |
| 体外活性 | Tyr-Gly-Gly-Phe-Met-OH,亦称为甲硫氨酸脑啡肽(MENK）,是一种内源性神经肽,在神经内分泌和免疫系统中扮演关键角色。MENK通过与免疫细胞和癌细胞上的阿片受体结合,具有免疫调节活性,并可用于癌症生物治疗。癌症患者的临床试验研究表明,MENK直接激活免疫细胞并通过抑制调节性T细胞(Tregs）发挥作用。MENK还可能通过与肿瘤细胞上或内的阿片受体结合,改变肿瘤微环境。这些作用机制在生物学上具有重要意义,并且在癌症免疫疗法中具有潜在应用。此外,它们揭示了内分泌系统和免疫系统之间的关系。 |
| 存储条件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 40 mg/mL (69.73 mM), Sonication is recommended. |
| 关键字 | Tyr-Gly-Gly-Phe-Met-OH | TyrGlyGlyPheMetOH | Tyr Gly Gly Phe Met OH | OpioidReceptor | Opioid Receptor | Inhibitor | inhibit |
| 相关产品 | Docusate sodium | Naltrexone hydrochloride | Progesterone | SCH 221510 | Amentoflavone | Mirtazapine | Mianserin hydrochloride | (-)-Menthol | Bevenopran | Naloxone HCl Dihydrate | JNJ-20788560 | Trimebutine |
| 相关库 | Anti-Cancer Active Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | Peptide Compound Library | Anti-Aging Compound Library | Natural Product Library | GPCR Compound Library | Membrane Protein-targeted Compound Library | Anti-Neurodegenerative Disease Compound Library | Immunology/Inflammation Compound Library | Pain-Related Compound Library | Natural Product Library for HTS |
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