商品介绍

Product Introduction

Bioactivity

名称	Endomorphin 1 acetate
描述	Endomorphin 1 acetate is a selective and highly effective μ-opioid receptor agonist with anti-nociceptive and analgesic effects. Endomorphin 1 acetate shows high affinity for kappa3 and can be used to study neurological diseases.
体外活性	用各种浓度的 Endomorphin 1 acetate 处理CACO-2细胞。当单独将细胞与 Endomorphin 1 acetate 孵育时,未检测到基底IL-8产生的变化。然而,与单独使用IL-1β处理的细胞相比,在IL-1β存在下用 Endomorphin 1 acetate 处理CACO-2细胞显着增加了IL-8。[1]
体内活性	雄性Sprague Dawley大鼠(n = 48）被随机分为四组(n = 12/组）：i）对照组,LAD结扎,没有其他干预措施150分钟； ii）IR组：LAD连接30分钟(缺血）,并在体内进行120分钟的排列； iii）IPO组,缺血30分钟后,在再灌注前进行了三个LAD夹紧15秒的速率,并在再灌注前进行了15秒。 IV）EM50组：在LAD连接25分钟后静脉内给予 Endomorphin 1 acetate(50μg/kg）,随后在体内再生120分钟。在IR,IPO和 Endomorphin 1 acetate 组中,与对照组相比,LDH和CK-MB活性明显更高。与IR组相比,IPO和 Endomorphin 1 acetate 组的LDH和CK-MB活性显着降低。与对照组相比,在IR组中,IL-6和TNF-α水平显着升高。与IR组相比,IPO和 Endomorphin 1 acetate 组的IL-6和TNF-α水平显着降低。[2]
存储条件	keep away from moisture,store at low temperature,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (5.96 mM), Sonication is recommended. DMSO : 100 mg/mL (149.09 mM), Sonication is recommended.
关键字	μ-opioid receptor \| OpioidReceptor \| Opioid Receptor
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