| 描述 | Getagozumab is a humanized IgG4-kappa monoclonal antibody that specifically targets endothelin receptor type A (EDNRA) with potent antagonistic activity. Getagozumab significantly lowered pulmonary arterial pressure in both hypoxia-induced and monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) monkey models and further attenuated the associated pulmonary arterial and right ventricular hypertrophy. |